Journal article
Yang Yang, Shi-Liang Shi, Dawen Niu, Peng Liu, Stephen L. Buchwald
Science, vol. 349, 2015, pp. 62-66
Science, vol. 349, 2015, pp. 62-66
Cite
Cite
APA
Click to copy
Yang, Y., Shi, S.-L., Niu, D., Liu, P., & Buchwald, S. L. (2015). 58. Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines. Science, 349, 62–66. https://doi.org/10.1126/science.aab3753
Chicago/Turabian
Click to copy
Yang, Yang, Shi-Liang Shi, Dawen Niu, Peng Liu, and Stephen L. Buchwald. “58. Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines.” Science 349 (2015): 62–66.
MLA
Click to copy
Yang, Yang, et al. “58. Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines.” Science, vol. 349, 2015, pp. 62–66, doi:10.1126/science.aab3753.
BibTeX Click to copy
@article{yang2015a,
title = {58. Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines},
year = {2015},
journal = {Science},
pages = {62-66},
volume = {349},
doi = {10.1126/science.aab3753},
author = {Yang, Yang and Shi, Shi-Liang and Niu, Dawen and Liu, Peng and Buchwald, Stephen L.}
}
Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins—an important yet unexploited class of abundant feedstock chemicals—into highly enantioenriched α-branched amines (≥96% enantiomeric excess) featuring two minimally differentiated aliphatic substituents.
